Marc Minkowski was initially a bassoonist, but took up conducting at a very young age under Charles Bruck at the Pierre Monteux Memorial School in the United States. At the age of 19, he founded Les Musiciens du Louvre, an ensemble that plays an active part in the Baroque revival and with which he is also dusting off the French repertoire (Lully, Rameau, Campra, Marais, Mouret, Rebel, Mondonville and others) and Handel (Il trionfo del Tempo, Amadigi, Teseo, Ariodante, Giulio Cesare, Hercules, Semele) before tackling Mozart, Rossini, Offenbach, Bizet and Wagner.
Marc Minkowski has travelled extensively throughout Europe, both with and without his orchestra: from Salzburg (Die Entführung aus dem Serail, Die Fledermaus, Mitridate, Così fan tutte, Lucio Silla in 2013) to Brussels (La Cenerentola, Don Quichotte by Massenet, Les Huguenots by Meyerbeer, Il trovatore in 2012) and from Aix-en-Provence (L’incoronazione di Poppea, Le nozze di Figaro, Idomeneo, Sérail, Don Giovanni with the London Symphony Orchestra in 2013) to Zurich (Il trionfo del Tempo, Giulio Cesare, Agrippina, Les Boréades, Fidelio, La Favorite), not forgetting the Musikfest Bremen.
He is regularly programmed at the Opéra de Paris (Platée, Idomeneo, Die Zauberflöte, Ariodante, Giulio Cesare, Iphigénie en Tauride, Mireille) and at the Théâtre du Châtelet (La Belle Hélène, La Grande‐Duchesse de Gérolstein, Carmen, Die Feen by Wagner). He has also performed at the Opéra-Comique theatre, where he revived La Dame blanche by Boieldieu, conducted Pelléas et Mélisande in 2002 for the work's centenary, and Cendrillon by Massenet. Mark Minkowski has also performed at international venues: in Venice (Le Domino noir by Auber), Moscow (staged premiere of Pelléas in Russia), Berlin (Robert le Diable, Il trionfo del Tempo), Amsterdam (Roméo et Juliette, Iphigénie en Aulide and Iphigénie en Tauride), Vienna at the Theater an der Wien (Hamlet ) or at the Staatsoper, where, in 2010, Les Musiciens du Louvre Grenoble was the first French orchestra to perform in the pit (Alcina by Handel).
Marc Minkowski also regularly hosts symphony orchestras, with which his repertoire is increasingly shifting towards the 19th and 20th centuries: Bruckner, Mahler, Grieg, Ravel, Stravinsky, Lili Boulanger, Albert Roussel, John Adams and Olivier Greif. He is often invited to Germany by the Staatskapelle in Dresdes, the Berlin Philharmonic, the Deutsches Symphonie-Orchester Berlin, the Leipzig Gewandhaus, the Bayerische Staatsoper or the Frankfurt Radio Orchestra. He also conducted the Mahler Chamber Orchestra, the Wiener Symphoniker, the Mozarteum Salzburg, the BBC Symphony Orchestra, the Cleveland Orchestra, the Los Angeles Philharmonic, the Swedish Radio Orchestra, the Finnish Radio Orchestra, the Orchestre National du Capitole in Toulouse, the Mariinsky Theatre Orchestra and the Qatar Philharmonic Orchestra. He has been guest conductor of the Wiener Philharmoniker on several occasions.
In 2009, the ensemble Les Musiciens du Louvre Grenoble was invited to take part in a performance of Haydn's complete London symphonies, recorded live at the Wiener Konzerthaus by Naïve, their exclusive recording company since 2007. It was a frank success and the same venue invited them back for the complete Schubert symphonies in 2012. In 2013, he recorded The Flying Dutchman - versions by Wagner and Dietsch - with his orchestra, and in 2014 the St John Passion by Bach.
Marc Minkowski is the artistic director of the Mozart Week in Salzburg. He had been responsible for the festival's programme up to 2017. In January 2015, he invited Bartabas and his Equestrian Academy for a new production of Mozart's Davide penitente.
In June 2011, he created the Ré Majeure festival on the Ile de Ré.